Transition metal-catalyzed C-H activation reactions: diastereoselectivity and enantioselectivity

Chem Soc Rev. 2009 Nov;38(11):3242-72. doi: 10.1039/b816707a. Epub 2009 Oct 1.


This critical review discusses historical and contemporary research in the field of transition metal-catalyzed carbon-hydrogen (C-H) bond activation through the lens of stereoselectivity. Research concerning both diastereoselectivity and enantioselectivity in C-H activation processes is examined, and the application of concepts in this area for the development of novel carbon-carbon and carbon-heteroatom bond-forming reactions is described. Throughout this review, an emphasis is placed on reactions that are (or may soon become) relevant in the realm of organic synthesis (221 references).

Publication types

  • Review

MeSH terms

  • Catalysis
  • Organic Chemicals / chemical synthesis*
  • Stereoisomerism
  • Transition Elements


  • Organic Chemicals
  • Transition Elements