Serum levels of vascular endothelial growth factor and its receptors in patients with severe autism

Clin Biochem. 2010 Feb;43(3):317-9. doi: 10.1016/j.clinbiochem.2009.10.005. Epub 2009 Oct 20.

Abstract

Objective: To study vascular endothelial growth factor (VEGF) and its soluble receptors sVEGFR-1 and -2 in autism.

Design and methods: We measured serum levels of angiogenic molecules in 22 patients with severe autism and 28 controls.

Results: Patients and controls had similar sVEGFR-2 levels, but VEGF levels were lower and sVEGFR-1 higher in patients with autism.

Conclusion: The imbalance between VEGF and its receptor sVEGFR-1 may be involved in the pathophysiology of autism.

MeSH terms

  • Adolescent
  • Adult
  • Autistic Disorder / blood*
  • Autistic Disorder / physiopathology
  • Biomarkers / blood
  • Female
  • Humans
  • Male
  • Vascular Endothelial Growth Factor A / blood*
  • Vascular Endothelial Growth Factor Receptor-1 / blood*
  • Vascular Endothelial Growth Factor Receptor-2 / blood*
  • Young Adult

Substances

  • Biomarkers
  • Vascular Endothelial Growth Factor A
  • Vascular Endothelial Growth Factor Receptor-1
  • Vascular Endothelial Growth Factor Receptor-2