Regulation of cell death by the ubiquitin-proteasome system

Curr Opin Cell Biol. 2009 Dec;21(6):878-84. doi: 10.1016/ Epub 2009 Oct 21.


The regulation of apoptosis (programmed cell death) has been the subject of a vast body of research because of its implications in normal development, tissue homeostasis and a wide range of diseases. The ubiquitin-proteasome system (UPS) plays a prominent role in the control of apoptosis by targeting key cell death proteins, including caspases, the central executioners of apoptosis. Here we summarize the major findings on the function of the UPS in both pro- and anti-apoptotic regulation.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Apoptosis / physiology*
  • Caspases / metabolism
  • Humans
  • Proteasome Endopeptidase Complex / metabolism*
  • Signal Transduction
  • Ubiquitin / metabolism*


  • Ubiquitin
  • Caspases
  • Proteasome Endopeptidase Complex