A gene from the region of the human X inactivation centre is expressed exclusively from the inactive X chromosome

Nature. 1991 Jan 3;349(6304):38-44. doi: 10.1038/349038a0.


X-chromosome inactivation results in the cis-limited dosage compensation of genes on one of the pair of X chromosomes in mammalian females. Although most X-linked genes are believed to be subject to inactivation, several are known to be expressed from both active and inactive X chromosomes. Here we describe an X-linked gene with a novel expression pattern--transcripts are detected only from the inactive X chromosome (Xi) and not from the active X chromosome (Xa). This gene, called XIST (for Xi-specific transcripts), is a candidate for a gene either involved in or uniquely influenced by the process of X inactivation.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Base Sequence
  • Chromosome Mapping*
  • Dosage Compensation, Genetic*
  • Gene Expression*
  • Humans
  • Karyotyping
  • Molecular Sequence Data
  • Transcription, Genetic
  • X Chromosome*

Associated data

  • GENBANK/X52371
  • GENBANK/X52372
  • GENBANK/X56196
  • GENBANK/X56197
  • GENBANK/X56198
  • GENBANK/X56199
  • GENBANK/X57181
  • GENBANK/X57182
  • GENBANK/X57183
  • GENBANK/X57184