Successful treatment of immune reconstitution inflammatory syndrome in Whipple's disease using thalidomide

J Infect. 2010 Jan;60(1):79-82. doi: 10.1016/j.jinf.2009.09.017. Epub 2009 Oct 21.


A patient with classic Whipple's disease developed erythema nodosum leprosum-like lesions and fever one month after the beginning of an accurate therapy with trimethoprim-sulfamethoxazole. Immune reconstitution inflammatory syndrome was suspected, but corticosteroid therapy failed to improve the patient. Finally, thalidomide was used and successfully induced rapid improvement.

Publication types

  • Case Reports

MeSH terms

  • Humans
  • Immune Reconstitution Inflammatory Syndrome / drug therapy*
  • Immunosuppressive Agents / therapeutic use*
  • Male
  • Middle Aged
  • Thalidomide / therapeutic use*
  • Treatment Outcome
  • Trimethoprim, Sulfamethoxazole Drug Combination / therapeutic use
  • Whipple Disease / drug therapy*
  • Whipple Disease / immunology


  • Immunosuppressive Agents
  • Thalidomide
  • Trimethoprim, Sulfamethoxazole Drug Combination