hMOF, a KAT(8) with many lives

Hestia S Mellert; Steven B McMahon

doi:10.1016/j.molcel.2009.10.005

hMOF, a KAT(8) with many lives

Mol Cell. 2009 Oct 23;36(2):174-5. doi: 10.1016/j.molcel.2009.10.005.

Authors

Hestia S Mellert¹, Steven B McMahon

Affiliation

¹ Biomedical Graduate Studies, University of Pennsylvania, Philadelphia, PA 19104, USA.

PMID: 19854127
DOI: 10.1016/j.molcel.2009.10.005

Abstract

Dynamic lysine acetylation regulates proteins involved in diverse cellular processes, with individual enzymes often acetylating multiple substrates. Here, Li et al. (2009) show that the substrate specificity of hMOF/MYST1/KAT8 is controlled by differential interaction with two mutually exclusive partners.

MeSH terms

Acetylation
Animals
Apoptosis Regulatory Proteins / metabolism
Histone Acetyltransferases / metabolism*
Histones / metabolism
Humans
Models, Biological
Multiprotein Complexes / chemistry
Multiprotein Complexes / metabolism
Proto-Oncogene Proteins / metabolism
Tumor Suppressor Protein p53 / metabolism

Substances

Apoptosis Regulatory Proteins
BBC3 protein, human
Histones
Multiprotein Complexes
Proto-Oncogene Proteins
Tumor Suppressor Protein p53
Histone Acetyltransferases
KAT8 protein, human