The KDEL receptor: new functions for an old protein

FEBS Lett. 2009 Dec 3;583(23):3863-71. doi: 10.1016/j.febslet.2009.10.053. Epub 2009 Oct 23.


The KDEL receptor is a seven-transmembrane-domain protein that was first described about 20 years ago. Its well-known function is to retrotransport chaperones from the Golgi complex to the endoplasmic reticulum. Recent studies, however, have suggested that the KDEL receptor has additional functions. Indeed, we have demonstrated that chaperone-bound KDEL receptor triggers the activation of Src family kinases on the Golgi complex. This activity is essential in the regulation of Golgi-to-plasma membrane transport. However, the identification of different KDEL receptor interactors that are inconsistent with these established functions opens the possibility of further receptor activities.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Endocytosis
  • Endoplasmic Reticulum / metabolism
  • Humans
  • Molecular Chaperones / metabolism
  • Protein Transport
  • Receptors, Peptide / chemistry
  • Receptors, Peptide / metabolism*
  • src-Family Kinases / metabolism


  • KDEL receptor
  • Molecular Chaperones
  • Receptors, Peptide
  • src-Family Kinases