Adipocytokines in relation to Hodgkin lymphoma in children

Pediatr Blood Cancer. 2010 Feb;54(2):311-5. doi: 10.1002/pbc.22294.


This case-control study aims to explore the association of serum adiponectin/leptin with childhood Hodgkin lymphoma (HL). Study participants were 75 children with histologically confirmed HL, registered in the Nationwide Registry for Childhood Haematological Malignancies and 75 age- and gender-matched controls. Multiple conditional logistic regression analyses were performed, adjusting for sociodemographic and lifestyle parameters. Adiponectin levels were consistently higher among cases in all models with ORs >1.25; 95% CIs ranging from 0.9 to 1.8 and P-values from 0.09 to 0.20. By contrast, there was no association of serum leptin with HL. In conclusion, elevated serum adiponectin might be a risk factor for childhood HL.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adiponectin / blood*
  • Adolescent
  • Case-Control Studies
  • Child
  • Child, Preschool
  • Female
  • Greece / epidemiology
  • Hodgkin Disease / blood*
  • Hodgkin Disease / epidemiology
  • Humans
  • Infant
  • Infant, Newborn
  • Leptin / blood*
  • Logistic Models
  • Male
  • Multivariate Analysis
  • Risk Factors


  • Adiponectin
  • Leptin