Assessment of hyperpolarized 3He lung MRI for regional evaluation of interventional therapy: a pilot study in pediatric cystic fibrosis

J Magn Reson Imaging. 2009 Nov;30(5):981-8. doi: 10.1002/jmri.21949.


Purpose: To determine whether regional changes in lung ventilation in a group of pediatric cystic fibrosis (CF) patients following a course of chest physiotherapy could be detected with (3)He MRI.

Materials and methods: The reproducibility of lung ventilation volume measurements obtained with (3)He lung magnetic resonance imaging (MRI) was established in a group of five children with CF age 6-15 years. The same methodology was then used to evaluate whether standard chest physiotherapy (percussion and drainage) had any immediate effect on regional ventilated lung volumes in a further group of nine age-matched CF children (5-15 years).

Results: Global lung ventilation volumes remained the same within the limits of sensitivity derived from the reproducibility study; however, regional lung ventilation was observed to change in most patients after therapy.

Conclusion: (3)He MRI can be successfully used in children with CF, and has the sensitivity to detect regional quantitative changes in lung ventilation following chest physiotherapy.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Child
  • Cohort Studies
  • Cystic Fibrosis / pathology*
  • Helium / chemistry*
  • Humans
  • Image Processing, Computer-Assisted
  • Isotopes / chemistry*
  • Lung / pathology*
  • Magnetic Resonance Imaging / methods*
  • Magnetics
  • Oxygen / metabolism
  • Pilot Projects
  • Pulmonary Ventilation
  • Spirometry / methods


  • Isotopes
  • Helium
  • Oxygen