Bilateral deepening of upper lid sulcus from topical bimatoprost therapy

J Ocul Pharmacol Ther. 2009 Oct;25(5):471-2. doi: 10.1089/jop.2009.0019.

Abstract

Purpose: To report a new adverse effect related to treatment with bimatoprost.

Method: Case report. A 43-year-old Asian female with bilateral glaucoma was noticed to have bilateral deepening of upper lid sulcus 3 months after beginning treatment with bimatoprost 0.03%.

Results: Bimatoprost was discontinued due to cosmetic reasons, and there was improvement of the lid sulcus deepening bilaterally 4 weeks after stopping the drug.

Conclusions: Deepening of upper lid sulcus is one of the adverse effects related to treatment with bimatoprost. This effect may be more prominent in Asians who have relatively full upper lid sulcus.

Publication types

  • Case Reports

MeSH terms

  • Administration, Topical
  • Adult
  • Amides / adverse effects*
  • Amides / therapeutic use
  • Antihypertensive Agents / adverse effects*
  • Antihypertensive Agents / therapeutic use
  • Asian People
  • Bimatoprost
  • Cloprostenol / adverse effects
  • Cloprostenol / analogs & derivatives*
  • Cloprostenol / therapeutic use
  • Eyelid Diseases / chemically induced*
  • Female
  • Glaucoma, Open-Angle / drug therapy
  • Humans
  • Intraocular Pressure / drug effects
  • Ophthalmic Solutions

Substances

  • Amides
  • Antihypertensive Agents
  • Ophthalmic Solutions
  • Cloprostenol
  • Bimatoprost