Measuring patient-relevant benefits in pruritus treatment: development and validation of a specific outcomes tool

Br J Dermatol. 2009 Nov;161(5):1143-8. doi: 10.1111/j.1365-2133.2009.09328.x.


Background: The assessment of patient-relevant benefit is gaining importance in evaluating treatments. The 'Patient Benefit Index, standard version' questionnaire (PBI-S) is a validated instrument to assess patients' treatment needs and benefits in skin diseases. Before therapy, the patient rates the importance of predefined treatment goals; after therapy, he rates the extent to which these goals have been achieved. Thus far, no such instrument has been developed specifically for pruritus.

Objectives: Development and validation of a patient-relevant benefit questionnaire in the treatment of pruritus.

Methods: Fifty patients with pruritus were questioned on impairments due to pruritus and treatment needs. Four treatment objectives not already covered by the PBI-S were added to obtain a disease-specific instrument. This was tested for feasibility by 36 patients with pruritus and validated in a sample of 100 patients with pruritus.

Results: The instrument was feasible in clinical practice. There were < 2% missing values. Cronbach's alpha of the needs questionnaire was 0.93. Convergent validity was demonstrated with respect to reduction of pruritus and quality of life.

Conclusions: The PBI for pruritus is a feasible, reliable and valid instrument that is highly accepted in daily routine for recording patient-reported benefit.

Publication types

  • Research Support, Non-U.S. Gov't
  • Validation Study

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Feasibility Studies
  • Female
  • Humans
  • Male
  • Middle Aged
  • Needs Assessment
  • Outcome Assessment, Health Care / methods*
  • Outcome Assessment, Health Care / statistics & numerical data
  • Patient Satisfaction*
  • Pruritus / psychology
  • Pruritus / therapy*
  • Quality of Life
  • Reproducibility of Results
  • Surveys and Questionnaires*
  • Young Adult