Stroma in breast development and disease

Semin Cell Dev Biol. 2010 Feb;21(1):11-8. doi: 10.1016/j.semcdb.2009.10.003. Epub 2009 Oct 24.


It is increasingly apparent that normal and malignant breast tissues require complex local and systemic stromal interactions for development and progression. During development, mammary cell fate specification and differentiation require highly regulated contextual signals derived from the stroma. Likewise, during breast carcinoma development, the tissue stroma can provide tumor suppressing and tumor-promoting environments that serve to regulate neoplastic growth of the epithelium. This review focuses on the role of the stroma as a mediator of normal mammary development, as well as a critical regulator of malignant conversion and progression in breast cancer. Recognition of the important role of the stroma during the progression of breast cancers leads to the possibility of new targets for treatment of the initial breast cancer lesion as well as prevention of recurrence.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Animals
  • Breast Neoplasms* / pathology
  • Breast Neoplasms* / physiopathology
  • Breast* / anatomy & histology
  • Breast* / growth & development
  • Breast* / pathology
  • Cell Transformation, Neoplastic
  • Connective Tissue* / anatomy & histology
  • Connective Tissue* / pathology
  • Disease Progression
  • Female
  • Fibrosis / pathology
  • Humans
  • Stromal Cells / cytology
  • Stromal Cells / pathology
  • Stromal Cells / physiology*