Antibacterial clerodane diterpenes from Goldenrod (Solidago virgaurea)

Courtney M Starks; Russell B Williams; Matt G Goering; Mark O'Neil-Johnson; Vanessa L Norman; Jin-Feng Hu; Eliane Garo; Grayson W Hough; Stephanie M Rice; Gary R Eldridge

doi:10.1016/j.phytochem.2009.09.032

Antibacterial clerodane diterpenes from Goldenrod (Solidago virgaurea)

Phytochemistry. 2010 Jan;71(1):104-9. doi: 10.1016/j.phytochem.2009.09.032. Epub 2009 Oct 24.

Authors

Courtney M Starks¹, Russell B Williams, Matt G Goering, Mark O'Neil-Johnson, Vanessa L Norman, Jin-Feng Hu, Eliane Garo, Grayson W Hough, Stephanie M Rice, Gary R Eldridge

Affiliation

¹ Lead Discovery and Rapid Structure Elucidation Group, Sequoia Sciences Inc., 1912 Innerbelt Business Center Drive, St. Louis, MO 63114, USA. cstarks@sequoiasciences.com

PMID: 19857881
DOI: 10.1016/j.phytochem.2009.09.032

Abstract

Nine clerodane diterpenes, solidagoic acids C-I (1-7), cleroda-3,13(14)-dien-16,15:18,19-diolide (8) and cleroda-3,13(14)-dien-15,16:18,19-diolide (9) were isolated and characterised from the ethanol-ethyl acetate (1:1) extract of Solidago virgaurea. The structures were determined by NMR spectroscopic analysis. Several displayed moderate antibacterial activity against Staphylococcus aureus.

MeSH terms

Anti-Bacterial Agents / chemistry
Anti-Bacterial Agents / isolation & purification
Anti-Bacterial Agents / pharmacology*
Diterpenes / chemistry
Diterpenes / isolation & purification
Diterpenes / pharmacology*
Molecular Structure
Plant Extracts / chemistry
Plant Extracts / pharmacology*
Solidago / chemistry*
Staphylococcus aureus / drug effects*

Substances

Anti-Bacterial Agents
Diterpenes
Plant Extracts