Protective effect of oleic acid against acute gastric mucosal lesions induced by ischemia-reperfusion in rat

Saudi J Gastroenterol. 2007 Jan-Mar;13(1):17-20. doi: 10.4103/1319-3767.30460.


Aim: To assess the effect of Linoleic acid and oleic acid on gastric lesions induced by ischemia reperfusion.

Materials and methods: Twenty-six fasted rats were subjected to 30 minutes of gastric ischemia in the presence of 100 micromol/L hydrochloric acid and reperfusion periods of 60 minutes. The vascular permeability was quantified by measuring the extravasated Evans blue in the stomach.

Results: There were greater amount of leakage of Evans blue in gastric mucosa of rats treated with linoleic acid as compared to the control. Evans blue levels were significantly higher in gastric fluid as compared to the control. In contrast, Oleic acid significantly reduced the leakage of Evans blue in the gastric mucosa.

Conclusion: Oleic acid played a significant role in protecting the gastric mucosa from ischemia/reperfusion injury. Replacement of LA by OA in the diet could be beneficial in protecting the gastric mucosa.