Blood oxygenation level-dependent MRI of the skeletal muscle during ischemia in patients with peripheral arterial occlusive disease

Rofo. 2009 Dec;181(12):1157-61. doi: 10.1055/s-0028-1109786. Epub 2009 Oct 26.


Purpose: To compare calf muscle Blood Oxygenation Level-Dependent (BOLD) response during ischemia in patients suffering from peripheral arterial occlusive disease (PAOD) and age-matched non-PAOD subjects.

Materials and methods: PAOD patients with symptoms of intermittent calf claudication and an age-matched control group underwent T 2*-weighted single-shot multi-echo planar imaging on a whole-body MR scanner at 1.5 T. The muscle BOLD signal in the calf was acquired during 60 sec of baseline and 240 sec of ischemia induced by cuff compression. T 2* time courses in four calf muscles were evaluated.

Results: Significant differences in the mean T 2* values were noted after 150 sec of measurement (p < 0.05). Patients with PAOD revealed a significantly reduced BOLD signal decrease compared to an age-matched control group.

Conclusion: Potential cause for this observation may be changes in the structure and/or the metabolic turnover of the muscle in PAOD patients.

MeSH terms

  • Aged
  • Arterial Occlusive Diseases / blood
  • Arterial Occlusive Diseases / diagnosis*
  • Female
  • Humans
  • Image Enhancement / methods*
  • Image Processing, Computer-Assisted / methods*
  • Ischemia / blood
  • Ischemia / diagnosis*
  • Leg / blood supply*
  • Magnetic Resonance Imaging / methods*
  • Male
  • Middle Aged
  • Muscle, Skeletal / blood supply*
  • Oxygen / blood*
  • Reference Values
  • Sensitivity and Specificity


  • Oxygen