Immunotherapy of human cancers using gene modified T lymphocytes

Curr Gene Ther. 2009 Oct;9(5):396-408. doi: 10.2174/156652309789753338.

Abstract

Adoptive T cell therapies can produce objective clinical responses in patients with hematologic and solid malignancies. Genetic manipulation of T lymphocytes has been proposed as a means of increasing the potency and range of this anti-tumor activity. We now review how coupling expression of transgenic receptors with countermeasures against potent tumor immune evasion strategies is proving highly effective in pre-clinical models and describe how these approaches are being evaluated in human subjects.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Antigens / immunology
  • Genetic Engineering*
  • Humans
  • Immunotherapy*
  • Neoplasms / therapy*
  • T-Lymphocytes / immunology*

Substances

  • Antigens