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, 72 (11), 1944-8

The Lecanindoles, Nonsteroidal Progestins From the Terrestrial Fungus Verticillium Lecanii 6144

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The Lecanindoles, Nonsteroidal Progestins From the Terrestrial Fungus Verticillium Lecanii 6144

Deborah M Roll et al. J Nat Prod.

Abstract

Four new indolosesquiterpenes, lecanindoles A-D (1-4), were isolated from fermentations of the terrestrial fungus Verticillium lecanii 6144. The structures of compounds 1-4 were elucidated from analysis of spectroscopic data. Compound 2 was reduced to give 4 and its isomer 5. Compound 4 was found to be a potent and selective progesterone receptor agonist with an EC50 of 1.1 +/- 0.4 nM in a cell-based luciferase reporter assay.

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