Sage tea drinking improves lipid profile and antioxidant defences in humans

Int J Mol Sci. 2009 Sep 9;10(9):3937-3950. doi: 10.3390/ijms10093937.


Salvia officinalis (common sage) is a plant with antidiabetic properties. A pilot trial (non-randomized crossover trial) with six healthy female volunteers (aged 40-50) was designed to evaluate the beneficial properties of sage tea consumption on blood glucose regulation, lipid profile and transaminase activity in humans. Effects of sage consumption on erythrocytes' SOD and CAT activities and on Hsp70 expression in lymphocytes were also evaluated. Four weeks sage tea treatment had no effects on plasma glucose. An improvement in lipid profile was observed with lower plasma LDL cholesterol and total cholesterol levels as well as higher plasma HDL cholesterol levels during and two weeks after treatment. Sage tea also increased lymphocyte Hsp70 expression and erythrocyte SOD and CAT activities. No hepatotoxic effects or other adverse effects were observed.

Keywords: Salvia officinalis L.; antioxidant defences; human trial; lipid profile; type 2 diabetes mellitus.

Publication types

  • Clinical Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Administration, Oral
  • Adult
  • Alanine Transaminase / blood
  • Antioxidants / metabolism
  • Aspartate Aminotransferases / blood
  • Beverages*
  • Blood Glucose
  • Blood Pressure / drug effects
  • Catalase / metabolism
  • Cholesterol, LDL / blood
  • Cross-Over Studies
  • Diabetes Mellitus, Type 2 / blood
  • Diabetes Mellitus, Type 2 / drug therapy
  • Female
  • HSP70 Heat-Shock Proteins / metabolism
  • Heart Rate / drug effects
  • Hep G2 Cells
  • Humans
  • Hypoglycemic Agents / administration & dosage*
  • Lipids / blood
  • Middle Aged
  • Oxidative Stress / drug effects
  • Pilot Projects
  • Plant Extracts / administration & dosage*
  • Salvia officinalis / chemistry*
  • Superoxide Dismutase / metabolism


  • Antioxidants
  • Blood Glucose
  • Cholesterol, LDL
  • HSP70 Heat-Shock Proteins
  • Hypoglycemic Agents
  • Lipids
  • Plant Extracts
  • Catalase
  • Superoxide Dismutase
  • Aspartate Aminotransferases
  • Alanine Transaminase