Detection of DNA using bioactive paper strips

Chem Commun (Camb). 2009 Nov 21;(43):6640-2. doi: 10.1039/b911559e. Epub 2009 Sep 17.

Abstract

Paper strips containing DNA-conjugated microgels (MG) are used to achieve sensitive DNA detection in three steps: target DNA promoted ligation of a DNA primer to the MG-bound DNA, rolling circle amplification (RCA) between the primer and a circle DNA, and hybridization of the RCA products and a fluorescent DNA probe.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Base Sequence
  • DNA / analysis*
  • Nucleic Acid Hybridization
  • Paper*

Substances

  • DNA