A prenylflavone, artonin E, as arachidonate 5-lipoxygenase inhibitor

Biochem Pharmacol. 1991 Jan 1;41(1):115-8. doi: 10.1016/0006-2952(91)90018-z.

Abstract

Several naturally occurring prenylflavones were tested for their inhibitory actions on arachidonate 5-lipoxygenase purified from porcine leukocytes. Of the compounds tested, artonin E (5'-hydroxymorusin) exhibited the most potent inhibition on arachidonate 5-lipoxygenase (IC50 = 0.36 microM). Arachidonate 12-lipoxygenase purified from porcine leukocytes and human platelets, 15-lipoxygenase from rabbit reticulocytes and fatty acid cyclooxygenase from bovine vesicular glands were inhibited by the compound only at higher concentrations (IC50 = 2.3, 11, 5.2 and 2.5 microM, respectively).

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Dose-Response Relationship, Drug
  • Drugs, Chinese Herbal*
  • Flavonoids / pharmacology*
  • Humans
  • Leukocytes / enzymology
  • Lipoxygenase Inhibitors*
  • Structure-Activity Relationship

Substances

  • Drugs, Chinese Herbal
  • Flavonoids
  • Lipoxygenase Inhibitors
  • artonin E
  • morusin