FURTHER STUDIES ON THE NATURE OF THE PHENOMENON OF LOCAL SKIN REACTIVITY TO BACTERIAL FILTRATES: TOXIC FACTORS DERIVED FROM THE BLOOD SERUM

J Exp Med. 1932 Jul 31;56(2):291-305. doi: 10.1084/jem.56.2.291.

Abstract

Observations reported here seem to demonstrate the liberation or formation of a toxic principle in blood serum through a colloidal disturbance in the latter. The principle is able to elicit severe injury in tissues made vulnerable by a bacterial filtrate.