High-resolution optical coherence tomography correlates in ischemic radiation retinopathy

Cutan Ocul Toxicol. 2010 Mar;29(1):57-61. doi: 10.3109/15569520903331674.


Purpose: To find the abnormalities in various retinal layers caused by radiation retinopathy using spectral domain optical coherence tomography (SD-OCT).

Methods: We report a case of radiation retinopathy that was imaged using SD-OCT Copernicus (Optopol, Zawiercie, Poland). Analysis and synthesis of the OCT image were done using information both at the fovea and 2.5 mm temporal to the fovea.

Results: The layers that were reduced in thickness included the inner plexiform layer (47 microm vs. 74 microm), the inner nuclear layer (17 microm vs. 48 microm), and the outer plexiform layer (25 microm vs. 45 microm), whereas the layers with comparable thickness included the nerve fiber layer (24 microm vs. 25 microm), the outer nuclear layer (42 microm vs. 43 microm), the outer segment-inner segment junction (52 microm vs. 54 microm), and the retinal pigment epithelium (RPE) choriocapillaris layer (30 microm vs. 28 microm).

Conclusion: This report suggests that the radiation-induced damage was confined to the inner layers of the retina. However, secondary outer retinal layer changes may also occur, as suggested by functional derangements.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Eye Neoplasms / radiotherapy*
  • Fluorescein Angiography
  • Humans
  • Ischemia / etiology
  • Ischemia / pathology*
  • Lymphoma, Large B-Cell, Diffuse / radiotherapy*
  • Male
  • Radiation Injuries / etiology
  • Radiation Injuries / pathology*
  • Radiotherapy / adverse effects
  • Retina / pathology*
  • Retina / radiation effects
  • Retinal Diseases / etiology
  • Retinal Diseases / pathology*
  • Tomography, Optical Coherence*