Effect of almond-enriched high-monounsaturated fat diet on selected markers of inflammation: a randomised, controlled, crossover study

Br J Nutr. 2010 Mar;103(6):907-12. doi: 10.1017/S0007114509992480. Epub 2009 Oct 29.


Frequent consumption of nuts lowers the risk of CHD. While lowering blood lipids is one of the mechanisms for cardioprotection, the present study sought to determine whether monounsaturated fat-rich almonds also influence other CHD risk factors such as inflammation and haemostasis. This was a randomised, controlled, crossover feeding study with twenty-five healthy adults (eleven men; fourteen women), age 22-53 years. Following a 2 week run-in phase (34 % energy from fat), subjects were assigned in random order to three diets for 4 weeks each: a heart-healthy control diet with no nuts ( < 30 % energy from fat), low-almond diet and high-almond diet (10 % or 20 % isoenergetic replacement of control diet with almonds, respectively). Serum E-selectin was significantly lower on the high-almond diet compared with the control diet. E-selectin decreased as the percentage of energy from almonds increased (P < 0.0001). C-reactive protein (CRP) was lower in both the almond diets compared with the control diet. A clear dose response was not observed for either E-selectin or CRP. There was no effect of diet on IL-6 or fibrinogen. Tissue plasminogen activator antigen was significantly lower on the control and high-almond diets compared with the low-almond diet, although the values were within normal range. In conclusion, consumption of almonds influenced a few but not all of the markers of inflammation and haemostasis. A clear dose response was not observed for any of the markers studied.

Publication types

  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Biomarkers / blood*
  • C-Reactive Protein / analysis
  • Cross-Over Studies
  • Diet
  • Dietary Fats, Unsaturated / administration & dosage*
  • E-Selectin / blood
  • Energy Intake
  • Fatty Acids, Monounsaturated / administration & dosage*
  • Female
  • Fibrinogen / analysis
  • Hemostasis
  • Humans
  • Inflammation / blood*
  • Interleukin-6 / blood
  • Male
  • Middle Aged
  • Nuts*
  • Prunus*
  • Tissue Plasminogen Activator / blood


  • Biomarkers
  • Dietary Fats, Unsaturated
  • E-Selectin
  • Fatty Acids, Monounsaturated
  • Interleukin-6
  • Fibrinogen
  • C-Reactive Protein
  • Tissue Plasminogen Activator