Rejection of class I MHC-deficient haemopoietic cells by irradiated MHC-matched mice

Nature. 1991 Jan 24;349(6307):329-31. doi: 10.1038/349329a0.


Irradiated MHC-heterozygous mice often reject bone marrow cells transplanted from one of the homozygous parental strains, a phenomenon ('hybrid resistance') that appears to violate the laws of transplantation. Rejection of parental and allogeneic marrow cells also differs from conventional T cell-mediated rejection mechanisms as it is effected by NK1.1+ cells. To account for the unusual specificity of bone marrow rejection, it has been proposed that NK1.1+ cells destroy marrow cells that fail to express the full complement of self MHC class I (MHC-I) molecules. We show here that NK1.1+ cells in normal mice reject haemopoietic transplants from mice that are deficient for normal cell-surface MHC-I expression because of a targeted mutation in the beta 2-microglobulin gene. These findings demonstrate that deficient expression of MHC-I molecules renders marrow cells susceptible to rejection.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Antibodies, Monoclonal / pharmacology
  • Antigens, Surface / immunology
  • Bone Marrow / radiation effects
  • Bone Marrow Transplantation / immunology*
  • Graft Rejection*
  • Hematopoietic Stem Cells / immunology*
  • Histocompatibility Antigens Class I / deficiency*
  • Histocompatibility Antigens Class I / immunology
  • Killer Cells, Natural / immunology
  • Mice
  • Mice, Mutant Strains
  • Models, Biological
  • Receptors, Antigen, T-Cell / immunology
  • Spleen / immunology
  • T-Lymphocytes / immunology
  • Whole-Body Irradiation


  • Antibodies, Monoclonal
  • Antigens, Surface
  • Histocompatibility Antigens Class I
  • Receptors, Antigen, T-Cell