Self-hardening calcium deficient hydroxyapatite/gelatine foams for bone regeneration

J Mater Sci Mater Med. 2010 Mar;21(3):863-9. doi: 10.1007/s10856-009-3918-7. Epub 2009 Oct 30.

Abstract

In this work gelatine was used as multifunctional additive to obtain injectable self-setting hydroxyapatite/gelatine composite foams for bone regeneration. The foaming and colloidal stabilization properties of gelatine are well known in food and pharmaceutical applications. Solid foams were obtained by foaming liquid gelatine solutions at 50 degrees C, followed by mixing them with a cement powder consisting of alpha tricalcium phosphate. Gelatine addition improved the cohesion and injectability of the cement paste. After setting the foamed paste transformed into a calcium deficient hydroxyapatite. The final porosity, pore interconnectivity and pore size were modulated by modifying the gelatine content in the liquid phase.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Biocompatible Materials / chemistry*
  • Bone Cements
  • Bone Regeneration*
  • Bone Substitutes / chemistry
  • Calcium / chemistry*
  • Calcium Phosphates / chemistry
  • Cattle
  • Colloids / chemistry*
  • Durapatite / chemistry*
  • Gelatin / chemistry*
  • Porosity
  • Temperature
  • Time Factors
  • X-Ray Diffraction

Substances

  • Biocompatible Materials
  • Bone Cements
  • Bone Substitutes
  • Calcium Phosphates
  • Colloids
  • alpha-tricalcium phosphate
  • Gelatin
  • Durapatite
  • Calcium