Nonalbumin proteinuria in islet transplant recipients

Cell Transplant. 2010;19(1):119-25. doi: 10.3727/096368909X478641. Epub 2009 Oct 29.

Abstract

The aim of this study was to evaluate the importance of nonalbumin-predominant proteinuria on kidney function (KF) after islet transplantation (ITx). Twenty-four-hour proteinuria and albuminuria were available in 27 recipients. KF was assessed by serum creatinine and estimated glomerular filtration rate (eGFR) was calculated by Modification of Diet in Renal Disease formula. Correlations between eGFR and albuminuria (r = -0.422, p < 0.001) were higher than with proteinuria (r = -0.223, p < 0.001; p = 0.006 for comparison between correlations). Nineteen (70%) subjects had proteinuria >or= 300 mg/24 h during the follow-up. Subjects were divided into three groups according to urinary protein excretion patterns: no proteinuria (n = 8), nonalbumin-predominant (n = 8), and albumin-predominant (n = 11) proteinuria. Proteinuria >or= 500 mg/24 h was observed only among patients with albumin-predominant proteinuria (64%; p = 0.002) and these patients had the lowest eGFR means post-ITx (no proteinuria: 84.2 +/- 16.4 vs. nonalbumin: 69.1 +/- 13.8 vs. albumin-predominant proteinuria: 65.5 +/- 16.6 ml/min/1.73 m(2), p = 0.044 for first vs. last group). In conclusion, high frequency of proteinuria was observed after ITx. However, it seems to be milder and have less impact on KF when albumin is not the major source of proteinuria. Prospective evaluation of proteinuria, including tubular function markers, should be performed to elucidate the mechanisms of kidney damage in this population.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Albumins / metabolism
  • Causality
  • Cells, Cultured
  • Cohort Studies
  • Creatinine / blood
  • Diabetes Complications / physiopathology
  • Diabetes Complications / urine
  • Diabetes Mellitus / therapy*
  • Female
  • Glomerular Filtration Rate / physiology
  • Humans
  • Immunosuppressive Agents / adverse effects*
  • Islets of Langerhans Transplantation / adverse effects*
  • Islets of Langerhans Transplantation / immunology
  • Kidney Diseases / chemically induced
  • Kidney Diseases / physiopathology*
  • Kidney Function Tests
  • Kidney Tubules / drug effects
  • Kidney Tubules / physiology
  • Male
  • Middle Aged
  • Postoperative Complications / chemically induced
  • Postoperative Complications / physiopathology*
  • Postoperative Complications / prevention & control
  • Proteinuria / chemically induced
  • Proteinuria / physiopathology*
  • Proteinuria / prevention & control
  • Retrospective Studies
  • Risk Factors

Substances

  • Albumins
  • Immunosuppressive Agents
  • Creatinine