Vinegar decreases allergenic response in lentil and egg food allergy

Allergol Immunopathol (Madr). 2010 Mar-Apr;38(2):74-7. doi: 10.1016/j.aller.2009.08.003. Epub 2009 Oct 29.


Background: Food allergy results from an atypical response of the mucosal immune system to orally consumed allergens. Antacid medication inhibits the digestion of dietary proteins and causes food allergy. A decrease of the gastric pH might enhance the function of digestion and reduce the risk of food allergy.

Objective: To test a possible decrease in the allergenicity of powerful food allergens (egg, chicken, lentils) with the addition of vinegar during the cooking process.

Methods: We included seven patients who suffered from anaphylaxis due to egg, chicken and lentils. We added vinegar to egg, chicken and lentil processed extracts used for skin prick tests (SPT) and compared the wheal areas obtained with the same extracts sources and the same way but without vinegar addition. Immunodetection was performed with the different processed extracts and patients' sera. Only one patient consented food challenge with vinegar-marinated-chicken.

Results: Wheal areas were significantly minor with the food extract with vinegar. Immunodetection showed a decrease of the response with vinegar processed extracts.

Conclusions: Vinegar addition during the cooking process may decrease lentil and chicken allergenicity.

MeSH terms

  • Acetic Acid / immunology*
  • Adult
  • Anaphylaxis / immunology
  • Animals
  • Chickens / immunology*
  • Child
  • Child, Preschool
  • Cooking / methods*
  • Dietary Proteins / immunology
  • Egg Hypersensitivity / immunology*
  • Female
  • Food Hypersensitivity / immunology*
  • Humans
  • Immunoglobulin E / blood
  • Immunoglobulin E / immunology
  • Infant
  • Lens Plant / immunology*
  • Male
  • Middle Aged
  • Young Adult


  • Dietary Proteins
  • Immunoglobulin E
  • Acetic Acid