Sleep disorders in patients with multiple sclerosis

Sleep Med Rev. 2010 Apr;14(2):121-9. doi: 10.1016/j.smrv.2009.07.005. Epub 2009 Oct 29.


Patients with multiple sclerosis (MS) often have unrecognized sleep disorders at higher frequency than the general population. Sleep disorders such as sleep disordered breathing, insomnia, REM sleep behavior disorder, narcolepsy and restless legs syndrome have all been reported in the MS population. Notably, the most common symptom of MS is "fatigue," which itself has been correlated with sleep disturbances. Sleep disorders may impact the quality of life of the MS patient population. This paper reviews the association of sleep disorders with MS, and discusses the association of sleep disruption with MS fatigue.

Publication types

  • Review

MeSH terms

  • Fatigue / etiology
  • Fatigue / physiopathology
  • Humans
  • Multiple Sclerosis / complications*
  • Multiple Sclerosis / physiopathology
  • REM Sleep Behavior Disorder / etiology
  • REM Sleep Behavior Disorder / physiopathology
  • Restless Legs Syndrome / etiology
  • Restless Legs Syndrome / physiopathology
  • Sleep Apnea Syndromes / etiology
  • Sleep Apnea Syndromes / physiopathology
  • Sleep Initiation and Maintenance Disorders / etiology
  • Sleep Initiation and Maintenance Disorders / physiopathology
  • Sleep Wake Disorders / etiology*
  • Sleep Wake Disorders / physiopathology