Suppressors of cytokine signaling (SOCS) in T cell differentiation, maturation, and function

Trends Immunol. 2009 Dec;30(12):592-602. doi: 10.1016/ Epub 2009 Oct 30.


Cytokines are key modulators of T cell biology, but their influence can be attenuated by suppressors of cytokine signaling (SOCS), a family of proteins consisting of eight members, SOCS1-7 and CIS. SOCS proteins regulate cytokine signals that control the polarization of CD4(+) T cells into Th1, Th2, Th17, and T regulatory cell lineages, the maturation of CD8(+) T cells from naïve to "stem-cell memory" (Tscm), central memory (Tcm), and effector memory (Tem) states, and the activation of these lymphocytes. Understanding how SOCS family members regulate T cell maturation, differentiation, and function might prove critical in improving adoptive immunotherapy for cancer and therapies aimed at treating autoimmune and infectious diseases.

Publication types

  • Research Support, N.I.H., Intramural
  • Review

MeSH terms

  • Animals
  • Autoimmune Diseases / immunology
  • Autoimmune Diseases / therapy
  • Cell Differentiation
  • Communicable Diseases / immunology
  • Communicable Diseases / therapy
  • Humans
  • Immunologic Memory
  • Immunotherapy, Adoptive*
  • Lymphoid Progenitor Cells / immunology
  • Neoplasms / immunology
  • Neoplasms / therapy
  • Signal Transduction
  • Suppressor of Cytokine Signaling Proteins / genetics
  • Suppressor of Cytokine Signaling Proteins / immunology
  • Suppressor of Cytokine Signaling Proteins / metabolism*
  • T-Lymphocyte Subsets / immunology*
  • T-Lymphocyte Subsets / metabolism


  • Suppressor of Cytokine Signaling Proteins