How to Drive Your Helicase in a Straight Line

Cell. 2009 Oct 30;139(3):458-9. doi: 10.1016/j.cell.2009.10.016.


Helicases are molecular motors that move along and remodel DNA, RNA, and associated protein complexes. Helicases are often directional. By analyzing crystal structures in complexes with RNA and ATP analogs, Thomsen and Berger (2009) now elucidate the molecular basis for unidirectional motion by the hexameric RNA helicase Rho.

Publication types

  • Comment
  • Research Support, Non-U.S. Gov't

MeSH terms

  • DNA / metabolism
  • DNA Helicases / chemistry*
  • Escherichia coli / enzymology*
  • Models, Molecular
  • RNA / metabolism
  • RNA Helicases / chemistry


  • RNA
  • DNA
  • DNA Helicases
  • RNA Helicases