PI3 Kinase Signals BCR-dependent Mature B Cell Survival

Cell. 2009 Oct 30;139(3):573-86. doi: 10.1016/j.cell.2009.08.041.

Abstract

Previous work has shown that mature B cells depend upon survival signals delivered to the cells by their antigen receptor (BCR). To identify the molecular nature of this survival signal, we have developed a genetic approach in which ablation of the BCR is combined with the activation of specific, BCR dependent signaling cascades in mature B cells in vivo. Using this system, we provide evidence that the survival of BCR deficient mature B cells can be rescued by a single signaling pathway downstream of the BCR, namely PI3K signaling, with the FOXO1 transcription factor playing a central role.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • B-Lymphocytes / cytology*
  • B-Lymphocytes / metabolism*
  • Cell Survival*
  • Mice
  • Mice, Knockout
  • Phosphatidylinositol 3-Kinases / metabolism*
  • Receptors, Antigen, B-Cell / metabolism*
  • Signal Transduction

Substances

  • Receptors, Antigen, B-Cell
  • Phosphatidylinositol 3-Kinases