The effect of oral magnesium therapy on visual field and ocular blood flow in normotensive glaucoma

Eur J Ophthalmol. 2010 Jan-Feb;20(1):131-5. doi: 10.1177/112067211002000118.


Purpose: To evaluate the effect of oral magnesium therapy on ocular blood flow and visual field perimetry indices in patients with normotensive glaucoma (NTG).

Methods: Fifteen patients with NTG (study group) received 300 mg oral magnesium citrate for 1 month, while 15 patients with NTG (control group) received no treatment. Blood magnesium level measurement, visual field analysis, and color Doppler imaging of the orbital vessels were done before treatment and at 1 month.

Results: In the study group, mean deviation improved from -3.7+/-1.9 (mean +/- standard deviation) at baseline to -2.5+/-1.8 at 1 month (p<0.05), and pattern standard deviation improved from 3.6+/-2.3 at baseline to 2.8+/-2.6 at 1 month (p<0.05). Color Doppler imaging indices did not change after magnesium therapy.

Conclusions: Oral magnesium therapy may provide improvement in the visual field, but does not seem to affect ocular blood flow in patients with NTG. Other mechanism than increased ocular blood flow may be responsible for the improvement in the visual field with oral magnesium therapy.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Administration, Oral
  • Blood Flow Velocity / drug effects
  • Ciliary Arteries / physiology*
  • Citric Acid / administration & dosage*
  • Female
  • Humans
  • Intraocular Pressure
  • Low Tension Glaucoma / physiopathology*
  • Magnesium / blood
  • Male
  • Middle Aged
  • Ophthalmic Artery / physiology*
  • Organometallic Compounds / administration & dosage*
  • Prospective Studies
  • Regional Blood Flow / drug effects
  • Retinal Artery / physiology*
  • Tonometry, Ocular
  • Ultrasonography, Doppler, Color
  • Visual Field Tests
  • Visual Fields / drug effects*


  • Organometallic Compounds
  • Citric Acid
  • Magnesium
  • magnesium citrate