Simultaneous vertical guided bone regeneration and guided tissue regeneration in the posterior maxilla using recombinant human platelet-derived growth factor: a case report

J Oral Implantol. 2009;35(5):251-6. doi: 10.1563/AAID-JOI-D-09-00004.1.


This clinical case report describes and demonstrates successful use of recombinant human platelet-derived growth factor (rhPDGF-BB) in conjunction with autogenous bone, anorganic bone mineral, and barrier membranes to reconstruct severe alveolar bone defects. A combined sinus augmentation and vertical alveolar ridge augmentation was successfully performed. In addition, a significant amount of periodontal bone gain was achieved in close apposition to a previously denuded root surface, which is significant from a periodontal standpoint, given the possibility of vertical periodontal regeneration.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Alveolar Bone Loss / surgery
  • Alveolar Ridge Augmentation
  • Bone Regeneration / drug effects*
  • Bone Substitutes
  • Bone Transplantation
  • Dental Implantation, Endosseous
  • Female
  • Guided Tissue Regeneration, Periodontal / methods*
  • Humans
  • Maxilla / surgery
  • Maxillary Sinus / surgery*
  • Oral Surgical Procedures, Preprosthetic / methods*
  • Platelet-Derived Growth Factor / pharmacology*
  • Recombinant Proteins / pharmacology
  • Vertical Dimension


  • Bone Substitutes
  • Platelet-Derived Growth Factor
  • Recombinant Proteins