A kinetic overview of the receptors involved in 1,25-dihydroxyvitamin D3 and 24,25-dihydroxyvitamin D3 signaling: a systems biology approach

Crit Rev Eukaryot Gene Expr. 2009;19(3):181-96. doi: 10.1615/critreveukargeneexpr.v19.i3.20.


The vitamin D endocrine system modulates an arsenal of important biological functions in more than 30 different tissues in short- and long-term perspectives. Two membrane receptors and one nuclear receptor are suggested to be involved in the vitamin D signaling system, but the function and physiological relevance of the receptors are debated. The complexity of the vitamin D endocrine system makes it necessary to combine experimental data with in silico simulations to get a holistic view of vitamin D-dependent regulation of tissue and cell physiology. This review focus on binding characteristics for the three putative vitamin D receptors and proposes a future systems biology approach including mathematical modeling that will be helpful together with experimental methods in depicting antitumoral and other biological effects promoted by the vitamin D endocrine system.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • 24,25-Dihydroxyvitamin D 3 / metabolism*
  • Animals
  • Calcitriol / metabolism*
  • Humans
  • Receptors, Calcitriol / metabolism*
  • Signal Transduction / genetics
  • Signal Transduction / physiology
  • Systems Biology
  • Vitamin D / metabolism*
  • Vitamins / metabolism*


  • Receptors, Calcitriol
  • Vitamins
  • Vitamin D
  • 24,25-Dihydroxyvitamin D 3
  • Calcitriol