Molecular mechanisms of enterotoxigenic Escherichia coli infection

Microbes Infect. 2010 Feb;12(2):89-98. doi: 10.1016/j.micinf.2009.10.002. Epub 2009 Oct 31.


Enterotoxigenic Escherichia coli (ETEC) are a major cause of diarrheal illness in developing countries, and perennially the most common cause of traveller's diarrhea. ETEC constitute a diverse pathotype that elaborate heat-labile and/or heat-stable enterotoxins. Recent molecular pathogenesis studies reveal sophisticated pathogen-host interactions that might be exploited in efforts to prevent these important infections. While vaccine development for these important pathogens remains a formidable challenge, extensive efforts that attempt to exploit new genomic and proteomic technology platforms in discovery of novel targets are presently ongoing.

Publication types

  • Review

MeSH terms

  • Adhesins, Escherichia coli / metabolism
  • Bacterial Vaccines
  • Dysentery / microbiology
  • Enterotoxigenic Escherichia coli / genetics
  • Enterotoxigenic Escherichia coli / metabolism
  • Enterotoxigenic Escherichia coli / pathogenicity*
  • Escherichia coli Infections / microbiology*
  • Fimbriae, Bacterial / metabolism
  • Humans
  • Integration Host Factors
  • Intestine, Small / microbiology
  • Virulence / genetics
  • Virulence Factors / chemistry
  • Virulence Factors / metabolism


  • Adhesins, Escherichia coli
  • Bacterial Vaccines
  • Integration Host Factors
  • Virulence Factors