Combination chemotherapy and radiotherapy in small-cell carcinoma of the lung

G A King; R Comis; S Ginsberg; J Goldberg; H T Dale; J Brown; P Dalal; C Chung; A Gottlieb

doi:10.1148/125.2.529

Combination chemotherapy and radiotherapy in small-cell carcinoma of the lung

Radiology. 1977 Nov;125(2):529-30. doi: 10.1148/125.2.529.

Authors

G A King, R Comis, S Ginsberg, J Goldberg, H T Dale, J Brown, P Dalal, C Chung, A Gottlieb

PMID: 198846
DOI: 10.1148/125.2.529

Abstract

A combination of chemotherapy (Cytoxan, vincristine, and CCNU) and radiation therapy was used to treat 37 patients with small-cell carcinoma of the lung. There was 49% complete remission and an overall 76% objective response with an overall median survival of 12.5 months and 17 months for those showing a complete response. No serious morbidity was observed.

MeSH terms

Carcinoma, Small Cell / drug therapy
Carcinoma, Small Cell / radiotherapy*
Cyclophosphamide / therapeutic use
Drug Therapy, Combination
Female
Humans
Lomustine / therapeutic use
Lung Neoplasms / drug therapy
Lung Neoplasms / radiotherapy*
Male
Middle Aged
Prospective Studies
Remission, Spontaneous
Vincristine / therapeutic use

Substances

Vincristine
Lomustine
Cyclophosphamide