Hemorheological disorders in diabetes mellitus

J Diabetes Sci Technol. 2008 Nov;2(6):1130-8. doi: 10.1177/193229680800200622.


The objective of the present study is to review hemorheological disorders in diabetes mellitus. Several key hemorheological parameters, such as whole blood viscosity, erythrocyte deformability, and aggregation, are examined in the context of elevated blood glucose level in diabetes. The erythrocyte deformability is reduced, whereas its aggregation increases, both of which make whole blood more viscous compared to healthy individuals. The present paper explains how the increased blood viscosity adversely affects the microcirculation in diabetes, leading to microangiopathy.

Keywords: blood viscosity; diabetes mellitus; erythrocyte deformability and aggregation; hemorheological disorders; microangiopathy.