Cohesin: Its Roles and Mechanisms

Annu Rev Genet. 2009;43:525-58. doi: 10.1146/annurev-genet-102108-134233.

Abstract

The cohesin complex is a major constituent of interphase and mitotic chromosomes. Apart from its role in mediating sister chromatid cohesion, it is also important for DNA double-strand-break repair and transcriptional control. The functions of cohesin are regulated by phosphorylation, acetylation, ATP hydrolysis, and site-specific proteolysis. Recent evidence suggests that cohesin acts as a novel topological device that traps chromosomal DNA within a large tripartite ring formed by its core subunits.

Publication types

  • Review

MeSH terms

  • Animals
  • Cell Cycle Proteins / metabolism*
  • Chromosomal Proteins, Non-Histone / metabolism*
  • Chromosomes / metabolism
  • DNA / metabolism
  • Humans
  • Models, Biological

Substances

  • Cell Cycle Proteins
  • Chromosomal Proteins, Non-Histone
  • cohesins
  • DNA