A Bayesian adaptive design for two-stage clinical trials with survival data

Lifetime Data Anal. 2009 Dec;15(4):468-92. doi: 10.1007/s10985-009-9134-4. Epub 2009 Nov 4.

Abstract

A randomized two-stage adaptive Bayesian design is proposed and studied for allocation and comparison in a phase III clinical trial with survival time as treatment response. Several exact and limiting properties of the design and the follow-up inference are studied, both numerically and theoretically, and are compared with a single-stage randomized procedure. The applicability of the proposed methodology is illustrated by using some real data.

MeSH terms

  • Algorithms
  • Bayes Theorem*
  • Clinical Trials as Topic* / ethics
  • Clinical Trials as Topic* / statistics & numerical data
  • Humans
  • Research Design
  • Survival Analysis*