Subclinical atherosclerosis in patients with chronic psoriasis: a potential association

J Eur Acad Dermatol Venereol. 2010 Jun;24(6):661-6. doi: 10.1111/j.1468-3083.2009.03481.x. Epub 2009 Nov 2.


Background: The immunological abnormalities that lead to the development of psoriasis suggest that these patients may be at increased risk for other inflammatory state which may enhance atherosclerosis.

Objective: To assess the presence of subclinical atherosclerosis in psoriatic patients who haven't associated traditional cardiovascular risk factors, and to correlate these findings with colour Doppler echocardiographic parameters.

Methods: The study included 80 patients with chronic psoriasis together with 50 age and sex matched healthy volunteers served as control group. Patients who had classic cardiovascular risk factors or had cardiovascular or cerebrovascular events were excluded. Carotid artery intima-media thickness (IMT) and carotid plaques were measured in the carotid arteries by using high-resolution B-mode ultrasound. Also, echocardiographic study was performed using ultrasound imaging system in all cases and controls.

Results: Patients with psoriasis had increased carotid artery IMT compared with controls (means 0.9 +/- 0.2 mm vs. 0.7 +/- 0.1 mm; P < 0.001). Carotid IMT positively correlated with patients age, duration of the disease and severity of psoriasis. There was no significant difference in echocardiographic parameters in psoriatic patients compared with controls, also no significant correlation between carotid IMT and echocardiographic parameters were observed in psoriatic patients.

Conclusion: The increased carotid artery IMT in patients with chronic psoriasis suggesting that chronic psoriasis is associated with subclinical atherosclerosis with increased risk of cardiovascular disease. So, dermatologists should advice their patients to avoid traditional cardiovascular risk factors and to routinely checkup to reduce cardiovascular morbidity and mortality.

MeSH terms

  • Adult
  • Age Factors
  • Aged
  • Atherosclerosis / epidemiology*
  • Carotid Arteries / diagnostic imaging
  • Case-Control Studies
  • Chronic Disease
  • Echocardiography, Doppler, Color
  • Female
  • Humans
  • Male
  • Middle Aged
  • Psoriasis / complications*
  • Regression Analysis
  • Retrospective Studies
  • Risk Factors
  • Severity of Illness Index
  • Tunica Intima / diagnostic imaging
  • Tunica Media / diagnostic imaging