Comparison of critical drug-drug interaction listings: the Department of Veterans Affairs medical system and standard reference compendia

Clin Pharmacol Ther. 2010 Jan;87(1):48-51. doi: 10.1038/clpt.2009.198. Epub 2009 Nov 4.


The objective of this study was to evaluate the agreement among the US Department of Veterans Affairs (VA) listing of "critical" drug-drug interactions (DDIs) and two standard drug-interaction compendia. A list of critical DDIs, as defined by the VA, was compared with two standard commercially available compendia (Micromedex DRUG-REAX and Drug Interactions: Analysis and Management (DIAM)) in order to determine the level of agreement among the systems. Of 982 DDIs classified as critical by the VA, only 136 DDIs (13.7%) were considered critical in all three systems. Our conclusion was that, overall, there is poor agreement among the compendia and the VA system.

Publication types

  • Comparative Study

MeSH terms

  • Drug Information Services / standards*
  • Drug Interactions* / physiology
  • Drug-Related Side Effects and Adverse Reactions
  • Humans
  • Pharmaceutical Preparations / metabolism
  • Pharmacopoeias as Topic / standards*
  • United States
  • United States Department of Veterans Affairs / standards*


  • Pharmaceutical Preparations