Glycogen synthase kinase 3 in the world of cell migration

Dev Growth Differ. 2009 Dec;51(9):735-42. doi: 10.1111/j.1440-169X.2009.01141.x. Epub 2009 Nov 5.


Glycogen synthase kinase 3 (GSK3) is one of the few master switch kinases that regulate many aspects of cell functions. Recent studies on cell polarization and migration have shown that GSK3 is also essential for proper regulation of these processes. GSK3 influences cell migration as one of the regulators of the spatiotemporally controlled dynamics of the actin cytoskeleton, microtubules, and cell-to-matrix adhesions. In this mini-review, the effects of GSK3 on these three aspects of cell migration will be discussed.

Publication types

  • Review

MeSH terms

  • Animals
  • Cell Communication / physiology
  • Cell Movement / genetics
  • Cell Movement / physiology*
  • Cytoskeleton / genetics
  • Cytoskeleton / metabolism
  • Extracellular Matrix / metabolism
  • Extracellular Matrix / physiology
  • Glycogen Synthase Kinase 3 / genetics
  • Glycogen Synthase Kinase 3 / physiology*
  • Humans
  • Microtubules / metabolism
  • Microtubules / physiology
  • Models, Biological


  • Glycogen Synthase Kinase 3