Strongyloides stercoralis and the immune response

Parasitol Int. 2010 Mar;59(1):9-14. doi: 10.1016/j.parint.2009.10.009. Epub 2009 Nov 3.


The immune system is a highly evolved network of cells and molecules that can distinguish between invading pathogens and the body's own cells. But helminths, in their complex forms, are capable of down-regulating host immunity, protecting them from being eliminated and also minimizing severe pathology in the host. This review focuses on Strongyloides stercoralis and the immune responses in immunocompetent and/or immunocompromised individuals. It also highlights the implications for diagnosis/treatment and draws attention to an emerging public health disease. The solution to reducing the prevalence of strongyloidiasis remains on the effectiveness of pre-emptive measures in endemic communities, increased awareness, prompt early diagnosis as well as timely treatment.

Publication types

  • Review

MeSH terms

  • Animals
  • Humans
  • Immunocompetence
  • Immunocompromised Host
  • Strongyloides stercoralis / immunology*
  • Strongyloides stercoralis / pathogenicity
  • Strongyloidiasis / immunology*
  • Strongyloidiasis / parasitology