Plasma rich in growth factors and bone formation: a radiological and histomorphometric study in New Zealand rabbits

Braz Oral Res. Jul-Sep 2009;23(3):275-80. doi: 10.1590/s1806-83242009000300009.

Abstract

A radiographic and histomorphometric study was conducted on the influence of autologous plasma rich in growth factors (PRGF) upon bone healing in surgically created defects in rabbits. Radiographically, bone regeneration was significantly greater with the use of PRGF after one month (p = 0.005), though no differences were recorded after the second month. In the histomorphometric analysis one month after surgery, the defects filled with autologous bone plus PRGF showed a greater percentage of neoformed bone (35.01 +/- 5.31) than the control defects (22.90 +/- 12.23), though the differences were not significant. Two months after surgery, the defects filled with autologous bone showed greater regeneration (46.04 +/- 10.36%) than the control defects (30.59 +/- 5.69%), though the differences were not significant. The application of PRGF in the bone defects produced in New Zealand rabbits exerted a limited effect on local bone formation.

MeSH terms

  • Animals
  • Bone Regeneration / drug effects*
  • Bone Transplantation
  • Intercellular Signaling Peptides and Proteins / therapeutic use*
  • Male
  • Osteogenesis / drug effects*
  • Platelet-Rich Plasma / chemistry*
  • Rabbits
  • Radiography
  • Tibia / diagnostic imaging
  • Tibia / pathology
  • Tibia / surgery*
  • Wound Healing / drug effects*

Substances

  • Intercellular Signaling Peptides and Proteins