Internal fixator for use in the mouse

Injury. 2009 Nov:40 Suppl 4:S103-9. doi: 10.1016/j.injury.2009.10.044.


Knockout techniques enable us to expand our knowledge about bonerepair processes. Since they require the use of mice, such studies necessitate the development of special technologies. Mechano-biological reactions play a determining role in fracture healing, and therefore controlled conditions of stability are essential. Achieving fixation with a low-mass implant avoids uncontrolled inertial loading and enables free ambulation. A miniaturised version of conventional internal fixation as used in humans has been developed. The method consists of a plate-like internal fixator with locked screws. It permits compression fixation or splinting fixation at selectable levels of flexibility. A guide is used for standardised application of the fixator, the screws and the osteotomy. Locking the screws to the plate enables elevation of the fixator from the bone surface; therefore, minimal contact damage to the periosteal blood supply can be expected. The technology is now in use in several laboratories.

MeSH terms

  • Animals
  • Disease Models, Animal*
  • Equipment Design
  • Femur / blood supply
  • Fracture Fixation, Internal / instrumentation*
  • Fracture Fixation, Internal / methods
  • Internal Fixators*
  • Mechanical Phenomena
  • Mice
  • Mice, Knockout
  • Osteotomy / instrumentation
  • Osteotomy / methods
  • Reproducibility of Results