Eukaryotic and archaeal translation initiation factor 2: a heterotrimeric tRNA carrier

FEBS Lett. 2010 Jan 21;584(2):405-12. doi: 10.1016/j.febslet.2009.11.002.


Eukaryotic/archaeal translation initiation factor 2 (e/aIF2) is a heterotrimeric GTPase that plays a key role in selection of the correct start codon on messenger RNA. This review integrates structural and functional data to discuss the involvement of the three subunits in initiator tRNA binding. A possible role of the peripheral subunits in modulating the guanine nucleotide cycle on the core subunit is also addressed.

Publication types

  • Review

MeSH terms

  • Archaea / genetics
  • Archaea / metabolism*
  • Eukaryota / genetics
  • Eukaryota / metabolism*
  • Eukaryotic Initiation Factor-2 / chemistry
  • Eukaryotic Initiation Factor-2 / metabolism*
  • Protein Conformation
  • Protein Multimerization
  • Protein Subunits / chemistry
  • Protein Subunits / metabolism
  • RNA, Transfer / metabolism*


  • Eukaryotic Initiation Factor-2
  • Protein Subunits
  • RNA, Transfer