STITCH 2: An Interaction Network Database for Small Molecules and Proteins

Nucleic Acids Res. 2010 Jan;38(Database issue):D552-6. doi: 10.1093/nar/gkp937. Epub 2009 Nov 6.

Abstract

Over the last years, the publicly available knowledge on interactions between small molecules and proteins has been steadily increasing. To create a network of interactions, STITCH aims to integrate the data dispersed over the literature and various databases of biological pathways, drug-target relationships and binding affinities. In STITCH 2, the number of relevant interactions is increased by incorporation of BindingDB, PharmGKB and the Comparative Toxicogenomics Database. The resulting network can be explored interactively or used as the basis for large-scale analyses. To facilitate links to other chemical databases, we adopt InChIKeys that allow identification of chemicals with a short, checksum-like string. STITCH 2.0 connects proteins from 630 organisms to over 74,000 different chemicals, including 2200 drugs. STITCH can be accessed at http://stitch.embl.de/.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Aspirin / pharmacology
  • Computational Biology / methods*
  • Computational Biology / trends
  • Databases, Protein*
  • Drug Evaluation, Preclinical
  • Humans
  • Information Storage and Retrieval / methods
  • Internet
  • Models, Chemical
  • Pharmaceutical Preparations / chemistry
  • Protein Interaction Mapping / methods*
  • Proteins / chemistry
  • Software
  • User-Computer Interface

Substances

  • Pharmaceutical Preparations
  • Proteins
  • Aspirin