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, 462 (7273), 665-8

The Abscisic Acid Receptor PYR1 in Complex With Abscisic Acid

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The Abscisic Acid Receptor PYR1 in Complex With Abscisic Acid

Julia Santiago et al. Nature.

Abstract

The plant hormone abscisic acid (ABA) has a central role in coordinating the adaptive response in situations of decreased water availability as well as the regulation of plant growth and development. Recently, a 14-member family of intracellular ABA receptors, named PYR/PYL/RCAR, has been identified. These proteins inhibit in an ABA-dependent manner the activity of a family of key negative regulators of the ABA signalling pathway: the group-A protein phosphatases type 2C (PP2Cs). Here we present the crystal structure of Arabidopsis thaliana PYR1, which consists of a dimer in which one of the subunits is bound to ABA. In the ligand-bound subunit, the loops surrounding the entry to the binding cavity fold over the ABA molecule, enclosing it inside, whereas in the empty subunit they form a channel leaving an open access to the cavity, indicating that conformational changes in these loops have a critical role in the stabilization of the hormone-receptor complex. By providing structural details on the ABA-binding pocket, this work paves the way for the development of new small molecules able to activate the plant stress response.

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References

    1. Science. 2009 May 22;324(5930):1068-71 - PubMed
    1. Plant Physiol. 2009 Jul;150(3):1345-55 - PubMed
    1. Biochemistry. 2007 Sep 11;46(36):10328-38 - PubMed
    1. J Appl Crystallogr. 2007 Aug 1;40(Pt 4):658-674 - PubMed
    1. Cell. 2009 Jan 9;136(1):21-3 - PubMed

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