Design, synthesis, and antifungal activity of novel conformationally restricted triazole derivatives

Arch Pharm (Weinheim). 2009 Dec;342(12):732-9. doi: 10.1002/ardp.200900103.

Abstract

A series of new triazole derivatives were designed and synthesized on the basis of the active site of lanosterol 14alpha-demethylase from Candida albicans (CACYP51). 2-(2,4-Difluorophenyl)-3-(methyl-(3-phenoxyalkyl)amino)-1-(1H-1,2,4-triazol-1-yl)propan-2-ols show excellent in-vitro activity against most of the tested pathogenic fungi. The MIC(80) value of compound 8a against Candida albicans is 0.01 microM, which provides a good starting template for further structural optimization. The binding modes of the designed compounds were investigated by flexible molecular docking. The compounds interacted with CACYP51 through hydrophobic, van-der-Waals, and hydrogen-bonding interactions.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antifungal Agents / chemical synthesis*
  • Antifungal Agents / pharmacology*
  • Binding Sites / drug effects
  • Candida albicans / drug effects*
  • Drug Design
  • Microbial Sensitivity Tests
  • Models, Molecular
  • Molecular Conformation*
  • Molecular Structure
  • Structure-Activity Relationship
  • Triazoles / chemical synthesis*
  • Triazoles / pharmacology*

Substances

  • Antifungal Agents
  • Triazoles