Management of Frey syndrome using botulinum neurotoxin: a case report

J Can Dent Assoc. 2009 Nov;75(9):651-4.


Frey syndrome is manifested clinically by hemifacial flushing and sweating after a gustatory stimulus. Frey syndrome is usually secondary to traumatic injury in the parotid region and is thought to be the result of misdirected re-sprouting of damaged autonomic nerve fibres. In this case report, we highlight the clinical and psychosocial aspects of Frey syndrome from a patient"s perspective, outline the pathophysiology of the condition and current management strategies, and describe the use of botulinum neurotoxin in the treatment of Frey syndrome.

Publication types

  • Case Reports

MeSH terms

  • Adenoma, Pleomorphic / surgery
  • Botulinum Toxins, Type A / therapeutic use*
  • Female
  • Follow-Up Studies
  • Humans
  • Indicators and Reagents
  • Iodine
  • Neuromuscular Agents / therapeutic use*
  • Parotid Neoplasms / surgery
  • Postoperative Complications
  • Starch
  • Sweating, Gustatory / drug therapy*
  • Sweating, Gustatory / physiopathology


  • Indicators and Reagents
  • Neuromuscular Agents
  • Starch
  • Iodine
  • Botulinum Toxins, Type A